YM-022 [Ligand Id: 888] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL115121 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 269: 725-31 [PMID:7910212] |
| ChEMBL | Inhibitory concentration against radioligand [3 H]L-364,718 binding to gastrin/Cholecystokinin type A receptor from rat pancreas | B | 6.84 | pIC50 | 146 | nM | IC50 | J Med Chem (1997) 40: 331-341 [PMID:9022799] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]L-364718 from Cholecystokinin type A receptor from rat pancreas | B | 6.84 | pIC50 | 146 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 51-54 |
| CCK2 receptor in Human [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| GtoPdb | - | - | 9.2 | pIC50 | 0.63 | nM | IC50 | Regul Pept (2002) 103: 29-37 [PMID:11738246] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain | B | 9.96 | pIC50 | 0.11 | nM | IC50 | J Med Chem (1997) 40: 331-341 [PMID:9022799] |
| ChEMBL | Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain | B | 9.96 | pIC50 | 0.11 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 51-54 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
