YM-022 [Ligand Id: 888] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL115121 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| GtoPdb | - | - | 6.8 | pKi | - | - | - | J Pharmacol Exp Ther (1994) 269: 725-31 [PMID:7910212] |
| ChEMBL | Inhibitory concentration against radioligand [3 H]L-364,718 binding to gastrin/Cholecystokinin type A receptor from rat pancreas | B | 6.84 | pIC50 | 146 | nM | IC50 | J Med Chem (1997) 40: 331-341 [PMID:9022799] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]L-364718 from Cholecystokinin type A receptor from rat pancreas | B | 6.84 | pIC50 | 146 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 51-54 |
| CCK2 receptor in Human [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| GtoPdb | - | - | 9.2 | pIC50 | 0.63 | nM | IC50 | Regul Pept (2002) 103: 29-37 [PMID:11738246] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain | B | 9.96 | pIC50 | 0.11 | nM | IC50 | J Med Chem (1997) 40: 331-341 [PMID:9022799] |
| ChEMBL | Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain | B | 9.96 | pIC50 | 0.11 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 51-54 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
