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ChEMBL ligand: CHEMBL2057662 (3-(3-Stibonophenyl)Propanoic Acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.5 | pIC50 | 3150 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis | B | 5.33 | pKi | 4700 | nM | Ki | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.25 | pIC50 | 5670 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity phosphatase Cdc25C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2378] [UniProtKB: P30307] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
ChEMBL | Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity protein phosphatase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250381] [UniProtKB: Q16828] | ||||||||
ChEMBL | Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484] | ||||||||
GtoPdb | - | - | 5.05 | pIC50 | 8870 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-6 [PMID:22705189] |
ChEMBL | Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.05 | pIC50 | 8870 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Protein-tyrosine phosphatase mitochondrial 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0] | ||||||||
ChEMBL | Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4.87 | pIC50 | 13440 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467] | ||||||||
ChEMBL | Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.79 | pIC50 | 1620 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]