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ChEMBL ligand: CHEMBL2057662 (3-(3-Stibonophenyl)Propanoic Acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of N-terminal His-tagged Cdc25a catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.5 | pIC50 | 3150 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity phosphatase Cdc25B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4804] [UniProtKB: P30305] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate by secondary plot analysis | B | 5.33 | pKi | 4700 | nM | Ki | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.25 | pIC50 | 5670 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity phosphatase Cdc25C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2378] [UniProtKB: P30307] | ||||||||
ChEMBL | Inhibition of N-terminal His-tagged Cdc25c catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
ChEMBL | Inhibition of human recombinant His-tagged VHR using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Dual specificity protein phosphatase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250381] [UniProtKB: Q16828] | ||||||||
ChEMBL | Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
phosphatase and tensin homolog/Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052032] [GtoPdb: 2497] [UniProtKB: P60484] | ||||||||
GtoPdb | - | - | 5.05 | pIC50 | 8870 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-6 [PMID:22705189] |
ChEMBL | Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.05 | pIC50 | 8870 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
Protein-tyrosine phosphatase mitochondrial 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052033] [UniProtKB: Q8WUK0] | ||||||||
ChEMBL | Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 4.87 | pIC50 | 13440 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467] | ||||||||
ChEMBL | Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry | B | 5.79 | pIC50 | 1620 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL | Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2012) 20: 4371-4376 [PMID:22705189] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]