compound 39 [PMID: 23623673] [Ligand Id: 8875] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2387503 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX2 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| Leukotriene C4 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743183] [GtoPdb: 1391] [UniProtKB: Q16873] | ||||||||
| GtoPdb | - | - | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-78 [PMID:23623673] |
| ChEMBL | Inhibition of LTC4S (unknown origin) | B | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
| ChEMBL | Inhibition of mPGES1-mediated PGE2 release in IL1alpha-stimulated human A549 cells | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| ChEMBL | Inhibition of mPGES1 (unknown origin)-mediated PGE2 synthesis transfected in HEK293 cells coexpressing COX1 using arachidonic acid as substrate preincubated for 30 mins prior to substrate addition measured after 60 mins by HTRF assay | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| GtoPdb | - | - | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-78 [PMID:23623673] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| ChEMBL | Inhibition of thromboxane synthase (unknown origin) | B | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
