(2S,4S)-ketoconazole [Ligand Id: 8871] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL319160
Created with Highcharts 10.3.3ValuesChart context menuCYP11A1pKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCytochrome P450 11B1pKd BovinepKi BovinepIC50 BovinepEC50 Bovine02468Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCytochrome P450 19A1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • CYP21A2/Cytochrome P450 21 in Human [ChEMBL: CHEMBL2759] [GtoPdb: 1364] [UniProtKB: P08686]
  • CYP21A2 in Rat [GtoPdb: 1364]
Created with Highcharts 10.3.3ValuesChart context menuCytochrome P450 21pKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCytochrome P450 51pKd RatpKi RatpIC50 RatpEC50 Rat01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCYP7A1pKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat024681012Highcharts.com
  • CYP11B1 in Human [GtoPdb: 1359] [UniProtKB: P15538]
Created with Highcharts 10.3.3ValuesChart context menuCYP11B1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CYP11A1 in Human [GtoPdb: 1358] [UniProtKB: P05108]
GtoPdb - - 5.9 pIC50 - - - J Med Chem (1992) 35: 2818-25 [PMID:1495014]
CYP11A1/Cytochrome P450 11A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5246] [GtoPdb: 1358] [UniProtKB: P14137]
ChEMBL Inhibition of cholesterol side chain cleavage cytochrome P450 B 5.53 pIC50 2950 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
Cytochrome P450 11B1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2927] [UniProtKB: P15150]
ChEMBL Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450 B 6.61 pIC50 247 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
GtoPdb - - 5.4 pIC50 - - - J Med Chem (1992) 35: 2818-25 [PMID:1495014]
ChEMBL Inhibition of cytochrome P450 19A1 involved in steroid biosynthesis B 5.4 pIC50 3980 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
CYP21A2/Cytochrome P450 21 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2759] [GtoPdb: 1364] [UniProtKB: P08686]
ChEMBL Inhibition of Progesterone 21-hydroxylase cytochrome P450 21 B 5.35 pIC50 4460 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
CYP21A2 in Rat [GtoPdb: 1364]
GtoPdb - - 5.4 pIC50 4460 nM IC50 J Med Chem (1992) 35: 2818-25 [PMID:1495014]
CYP51A1/Cytochrome P450 51 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4981] [GtoPdb: 1374] [UniProtKB: Q64654]
ChEMBL Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51A B 5.8 pIC50 1600 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
CYP7A1 in Human [GtoPdb: 1354] [UniProtKB: P22680]
GtoPdb - - 9.7 pIC50 - - - J Med Chem (1992) 35: 2818-25 [PMID:1495014]
CYP7A1/Cytochrome P450 7A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2339] [GtoPdb: 1354] [UniProtKB: P18125]
ChEMBL Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylase B 6.26 pIC50 546 nM IC50 J Med Chem (1992) 35: 2818-2825 [PMID:1495014]
CYP11B1 in Human [GtoPdb: 1359] [UniProtKB: P15538]
GtoPdb - - 6.9 pIC50 - - - J Med Chem (1992) 35: 2818-25 [PMID:1495014]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]