compound 8a [PMID: 23713581] [Ligand Id: 8856] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2396718 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity protein phosphatase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396507] [UniProtKB: Q9H1R2] | ||||||||
| ChEMBL | Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Dual specificity protein phosphatase 23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396506] [UniProtKB: Q9BVJ7] | ||||||||
| ChEMBL | Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
| ChEMBL | Inhibition of recombinant VHR (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2] | ||||||||
| ChEMBL | Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrophotometric analysis | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
| ChEMBL | Inhibition of recombinant CD45 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666] | ||||||||
| ChEMBL | Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.47 | pIC50 | 340 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350] | ||||||||
| ChEMBL | Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.04 | pIC50 | 910 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923] | ||||||||
| ChEMBL | Inhibition of recombinant FAP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.41 | pIC50 | 390 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Inhibition of recombinant SHP-2 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase G1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3236] [UniProtKB: Q05209] | ||||||||
| ChEMBL | Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236] | ||||||||
| ChEMBL | Inhibition of recombinant HEPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467] | ||||||||
| ChEMBL | Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.33 | pIC50 | 470 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] | ||||||||
| ChEMBL | Inhibition of recombinant PTPepsilon (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 4.6 | pIC50 | >25000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470] | ||||||||
| ChEMBL | Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827] | ||||||||
| GtoPdb | - | - | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| ChEMBL | Inhibition of recombinant PTPmu (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
| ChEMBL | Inhibition of recombinant TCPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 4.95 | pIC50 | 11300 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Tyrosine-protein phosphatase non-receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396509] [UniProtKB: P26045] | ||||||||
| ChEMBL | Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378] | ||||||||
| ChEMBL | Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
