inhibitor A [PMID: 12482429] [Ligand Id: 8847] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL310981 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sphingomyelin phosphodiesterase 2/Neutral sphingomyelinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4712] [GtoPdb: 2515] [UniProtKB: O60906] | ||||||||
| ChEMBL | Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomes | B | 5.8 | pKi | 1600 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| ChEMBL | Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomes | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| ChEMBL | Inhibitory activity against schyphostatin of neutral sphingomyelinase (N-SMase) from bovine brain microsome | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
| sphingomyelin phosphodiesterase 2 in Bovine [GtoPdb: 2515] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | 1600 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 229-36 [PMID:12482429] |
| sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405] | ||||||||
| ChEMBL | Inhibitory activity against Acid sphingomyelinase from bovine brain microsome | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 229-236 [PMID:12482429] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
