ChEMBL ligand: CHEMBL461415
SHP/Nuclear receptor subfamily 0 group B member 2 in Human [ChEMBL: CHEMBL5603] [GtoPdb: 636] [UniProtKB: Q15466] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
SHP/Nuclear receptor subfamily 0 group B member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5603] [GtoPdb: 636] [UniProtKB: Q15466]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	J Med Chem (2008) 51: 5650-62 [PMID:18759424]
ChEMBL	Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP by liquid scintillation counting relative to 3-Cl-AHPC	B	6.3	pIC50	500	nM	IC50	J Med Chem (2008) 51: 5650-5662 [PMID:18759424]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL	Inhibition of SHP2 overexpressed in human KG1 cells	B	5.64	pIC50	2270	nM	IC50	J Med Chem (2008) 51: 5650-5662 [PMID:18759424]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]