compound 4 [PMID: 16495056] [Ligand Id: 8832] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL208528
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CYP2J2/Cytochrome P450 2J2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3491] [GtoPdb: 1332] [UniProtKB: P51589]
ChEMBL Inhibition of human recombinant CYP2J2 expressed in baculovirus-infected Sf9 insect cells B 6.8 pKi 160 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2777-2780 [PMID:16495056]
ChEMBL Inhibition of human recombinant CYP2J2 expressed in baculovirus-infected Sf9 insect cells B 6.4 pIC50 400 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2777-2780 [PMID:16495056]
GtoPdb Measuring CYP2J2-induced inhibition ebastine hydroxylation. - 6.8 pIC50 160 nM IC50 Bioorg Med Chem Lett (2006) 16: 2777-80 [PMID:16495056]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]