ChEMBL ligand: CHEMBL1403981
RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL	Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay	B	4.1	pIC50	79000	nM	IC50	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
GtoPdb	-	-	5.6	pKi	2500	nM	Ki	J Med Chem (2011) 54: 6548-62 [PMID:21882820]
ChEMBL	Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by Lineweaver-Burk plot	B	5.6	pKi	2500	nM	Ki	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL	Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET assay	B	4.89	pIC50	12800	nM	IC50	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL	Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay	B	5.59	pIC50	2600	nM	IC50	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL	Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 40 mins by FRET assay	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2011) 54: 6548-6562 [PMID:21882820]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]