compound 2 [Maurer et al., 2012] [Ligand Id: 8823] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2203548 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6] | ||||||||
| ChEMBL | Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| ChEMBL | Inhibition of sirtuin 1 (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2019) 161: 48-77 [PMID:30342425] |
| sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] | ||||||||
| ChEMBL | Inhibition of sirtuin 2 (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | Eur J Med Chem (2019) 161: 48-77 [PMID:30342425] |
| ChEMBL | Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | B | 5.01 | pIC50 | 9700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| ChEMBL | Inhibition of human recombinant Sirt2 using ZMAL as substrate after 4 hrs by fluorescent deacetylase assay | B | 5.55 | pIC50 | 2818.38 | nM | IC50 | Medchemcomm (2012) 3: 167-173 |
| ChEMBL | Inhibition of human recombinant Sirt2 using ZMAL as substrate after 4 hrs by fluorescent deacetylase assay | B | 5.55 | pIC50 | 2800 | nM | IC50 | Medchemcomm (2012) 3: 167-173 |
| sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminal Strep2-tagged SIRT5 expressed in Escherichia coli BL21 (DE3) using Abz-GVLK(glutaryl)AY(NO2)GV-NH2 as substrate in presence of NAD+ by fluorescence assay | B | 4.6 | pIC50 | 25200 | nM | IC50 | J Med Chem (2018) 61: 2460-2471 [PMID:29494161] |
| ChEMBL | Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-1053 [PMID:24900427] |
| GtoPdb | - | - | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1050-3 [PMID:24900427] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
