compound 57 [PMID: 16610804] [Ligand Id: 8771] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL443834 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cPLA2-4A/Cytosolic phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3816] [GtoPdb: 1424] [UniProtKB: P47712] | ||||||||
| ChEMBL | Inhibition of cPLA2alpha activity assessed by A23187-induced arachidonic acid release in human platelet | F | 6.24 | pIC50 | 570 | nM | IC50 | J Med Chem (2006) 49: 2611-2620 [PMID:16610804] |
| ChEMBL | Inhibition of human isolated cPLA2-alpha by vesicle assay | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2006) 49: 2611-2620 [PMID:16610804] |
| GtoPdb | Inhibition of human isolated cPLA2-4A in a lipid vesicle assay. | - | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2006) 49: 2611-20 [PMID:16610804] |
| ChEMBL | Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet | F | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (2006) 49: 2611-2620 [PMID:16610804] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
