tolfenamic acid [Ligand Id: 8769] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL121626 (Tolfenamic acid, Clotam, Clotam rapid)
  • AKR1C3/Aldo-keto-reductase family 1 member C3 in Human [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
  • 8.1
1 CHEMBL121626_lig_chart_1 Aldo-keto-reductase family 1 member C3 Human
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  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
  • This target only has 0 pki data point
  • 0
2 CHEMBL121626_lig_chart_2 Androgen Receptor Human
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  • transthyretin/Transthyretin in Human [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
  • This target only has 0 pki data point
  • 0
3 CHEMBL121626_lig_chart_3 Transthyretin Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
ChEMBL Inhibition of human AKR1C3 using S-(+)-1,2,3,4-tetrahydro-1-naphthol as substrate B 8.1 pKi 8 nM Ki J. Nat. Prod. (2012) 75: 716-721 [PMID:22506594]
GtoPdb - - 8.1 pKi 8 nM Ki J Biol Chem (2007) 282: 8368-79 [PMID:17166832]
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL Activity at androgen receptor ligand binding domain assessed as inhibition of SRC2-3 interaction after 2 hrs by fluorescence polarization assay B 4.33 pIC50 47000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 16074-16079 [PMID:17911242]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis B 6.82 pKd 150 nM Kd J. Med. Chem. (2015) 58: 6507-6515 [PMID:26214366]
ChEMBL Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blot analysis B 4.4 pIC50 40000 nM IC50 J. Med. Chem. (2015) 58: 6507-6515 [PMID:26214366]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]