ChEMBL ligand: CHEMBL290376 (DuP-714)
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] Thrombin in Bovine [ChEMBL: CHEMBL4471] [UniProtKB: P00735] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	In vitro for inhibition of plasmin	B	8.29	pKi	5.1	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Binding affinity against Thrombin.	B	10.39	pKd	0.04	nM	Kd	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of Coagulation factor II	B	10.38	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612]
ChEMBL	Inhibition constant for binding with thrombin was determined	B	10.39	pKi	0.04	nM	Ki	J Med Chem (1993) 36: 1831-1838 [PMID:8515421]
ChEMBL	In vitro for inhibition of thrombin.	B	10.39	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
GtoPdb	Affinity for thrombin active site.	-	10.39	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913–2918
ChEMBL	Inhibition of thrombin	B	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1997) 7: 1595-1600
ChEMBL	Inhibition of compound against thrombin mediated platelet activation and fibrinogen cleavage.	B	10.4	pKi	0.04	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735]
ChEMBL	Concentration necessary to double time for clot formation induced by bovine thrombin	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
GtoPdb	-	-	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913–2918
ChEMBL	Compound was tested in vitro for inhibition of tissue plasminogen activator	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
ChEMBL	Inhibitory activity against trypsin	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (1999) 9: 925-930 [PMID:10230612]
ChEMBL	Inhibition of trypsin	B	10.35	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1997) 7: 1595-1600
ChEMBL	Binding affinity against Trypsin	B	10.35	pKi	0.04	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Compound was tested in vitro for inhibition of trypsin	B	10.35	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (1996) 6: 2913-2918

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]