ChEMBL ligand: CHEMBL3113165 (ML-355, ML355, Vlx-1005, VLX-1005)
12S-LOX/Arachidonate 12-lipoxygenase in Human [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] 12S-LOX/Arachidonate 12-lipoxygenase in Mouse [ChEMBL: CHEMBL3225] [GtoPdb: 1387] [UniProtKB: P39655] There should be some charts here, you may need to enable JavaScript!
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
ChEMBL	Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Michaelis Menten equation analysis	B	6.14	pKi	720	nM	Ki	J Med Chem (2014) 57: 495-506 [PMID:24393039]
ChEMBL	Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Michaelis Menten equation analysis	B	6.46	pKi	350	nM	Ki	J Med Chem (2014) 57: 495-506 [PMID:24393039]
ChEMBL	Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysis	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2021) 46: 116347-116347 [PMID:34507163]
ChEMBL	Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	6.47	pIC50	340	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
GtoPdb	-	-	6.47	pIC50	340	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
12S-LOX/Arachidonate 12-lipoxygenase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3225] [GtoPdb: 1387] [UniProtKB: P39655]
ChEMBL	Inhibition of 12-LOX in mouse BTC3 cells assessed as inhibition of arachidonic acid/calcium ionophore-induced 12-HETE production after 4 hrs by ELISA	B	6	pIC50	1000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	5.01	pIC50	9700	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL	Inhibition of N-terminal His6-tagged human epithelial 15-LOX2 using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human 5-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]