ChEMBL ligand: CHEMBL235920
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Competitive inhibition of human 15-LOX1 using linoleic acid as substrate after 10 mins by Lineweaver-Burk plot analysis	B	7.14	pKi	73	nM	Ki	J Med Chem (2015) 58: 7850-7862 [PMID:26331552]
ChEMBL	Competitive inhibition of human 15-LOX-1 assessed as reduction in conversion of linoleic acid to 13(S)-HpODE incubated for 10 mins followed by linoleic acid addition by Lineweaver-Burk plot analysis	B	7.14	pKi	73	nM	Ki	Eur J Med Chem (2016) 122: 786-801 [PMID:27477687]
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	Inhibition of rabbit 15-lipoxygenase in presence of arachidonic acid	B	7.12	pIC50	75	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086]
ChEMBL	Inhibition of rabbit 15-lipoxygenase in presence of linoleic acid	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
GtoPdb	-	-	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5115-20 [PMID:17656086]
ChEMBL	Inhibition of human recombinant 15-lipoxygenase over-expressed in CHO cells	B	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5115-5120 [PMID:17656086]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]