compound 16 [PMID: 23412139] [Ligand Id: 8698] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2151181 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| ChEMBL | Inhibition of human recombinant BACE1 by FRET assay | B | 8.77 | pKi | 1.7 | nM | Ki | ACS Med Chem Lett (2012) 3: 897-902 [PMID:23412139] |
| ChEMBL | Inhibition of recombinant soluble human BACE1 catalytic domain using QSY7-EISEVNLDAEFC-Europium-amide as substrate preincubated for 10 mins followed by substrate addition measured after 1.5 hrs by time-resolved FRET assay | B | 8.77 | pKi | 1.7 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 2033-2045 [PMID:24704031] |
| GtoPdb | - | - | 8.77 | pKi | 1.7 | nM | Ki | ACS Med Chem Lett (2012) 3: 897-902 [PMID:23412139] |
| ChEMBL | Inhibition of BACE1 in HEK293 cells expressing APPswe/lon assessed as inhibition of amyloid beta-40 production | B | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2012) 3: 897-902 [PMID:23412139] |
| beta-secretase 2/Beta secretase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2525] [GtoPdb: 2331] [UniProtKB: Q9Y5Z0] | ||||||||
| ChEMBL | Inhibition of human recombinant BACE2 by FRET assay | B | 9 | pKi | <1 | nM | Ki | ACS Med Chem Lett (2012) 3: 897-902 [PMID:23412139] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
