GSK2033 [Ligand Id: 8690] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1093266 (GSK2033)
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  • Liver X receptor-α in Human [GtoPdb: 602] [UniProtKB: Q13133]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
GtoPdb - - 7.5 pIC50 - - - J Med Chem (2010) 53: 3412-6 [PMID:20345102]
ChEMBL Displacement of [N-methyl-3H]T1317 from human biotinylated LXRbeta LBD after 3 hrs by LEAD seeker binding assay B 7.5 pIC50 31.62 nM IC50 J Med Chem (2010) 53: 3412-3416 [PMID:20345102]
Liver X receptor-α in Human [GtoPdb: 602] [UniProtKB: Q13133]
GtoPdb - - 7 pIC50 - - - J Med Chem (2010) 53: 3412-6 [PMID:20345102]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]