ChEMBL ligand: CHEMBL1229259
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
ST14 transmembrane serine protease matriptase /Matriptase in Human [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] There should be some charts here, you may need to enable JavaScript!
kallikrein B1/Plasma kallikrein in Human [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 2/Transmembrane protease serine 2 in Human [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 6/Transmembrane protease serine 6 in Human [ChEMBL: CHEMBL1795139] [GtoPdb: 2422] [UniProtKB: Q8IU80] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of factor 10a	B	8.62	pKi	2.4	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6]
ChEMBL	Inhibition of matriptase	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952]
ChEMBL	Inhibition of plasma kallikrein	B	8.08	pKi	8.3	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Inhibition of plasmin	B	7.41	pKi	39	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Inhibition of thrombin	B	8.46	pKi	3.5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235]
GtoPdb	-	-	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839]
ChEMBL	Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader analysis	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
transmembrane serine protease 2/Transmembrane protease serine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393]
ChEMBL	Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescence plate reader analysis	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
GtoPdb	-	-	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839]
transmembrane serine protease 6/Transmembrane protease serine 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795139] [GtoPdb: 2422] [UniProtKB: Q8IU80]
ChEMBL	Inhibition of matriptase 2	B	6.77	pKi	170	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]