LDN-91946 [Ligand Id: 8661] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1190585 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibition of caspase3 | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| transglutaminase 2/Protein-glutamine gamma-glutamyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2730] [GtoPdb: 3015] [UniProtKB: P21980] | ||||||||
| ChEMBL | Inhibition of tissue transglutaminase | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ubiquitin specific peptidase 5/Ubiquitin carboxyl-terminal hydrolase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6158] [GtoPdb: 2431] [UniProtKB: P45974] | ||||||||
| ChEMBL | Inhibition of isopeptidase T | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ubiquitin C-terminal hydrolase L1/Ubiquitin carboxyl-terminal hydrolase isozyme L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6159] [GtoPdb: 2426] [UniProtKB: P09936] | ||||||||
| ChEMBL | Inhibition of UCHL1 | B | 5.55 | pKi | 2800 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ChEMBL | Inhibition of UCHL1 | B | 5.64 | pKi | 2300 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| GtoPdb | - | - | 5.64 | pKi | 2300 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3729-32 [PMID:17449248] |
| ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374] | ||||||||
| ChEMBL | Inhibition of UCHL3 | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
