compound 51 [PMID: 19743866] [Ligand Id: 8653] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1089597 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| complement factor B/Complement factor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5731] [GtoPdb: 2339] [UniProtKB: P00751] | ||||||||
| ChEMBL | Inhibition of human C3 convertase assessed as inhibition of C3a and C3b fragment production at pH 7.4 after 30 mins by SDS-PAGE | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 6042-6052 [PMID:19743866] |
| GtoPdb | - | - | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2009) 52: 6042-52 [PMID:19743866] |
| ChEMBL | Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assay | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2009) 52: 6042-6052 [PMID:19743866] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
