ChEMBL ligand: CHEMBL146746
Glutamyl aminopeptidase/Aminopeptidase A in Human [ChEMBL: CHEMBL3439] [GtoPdb: 1568] [UniProtKB: Q07075] Glutamyl aminopeptidase in Mouse [GtoPdb: 1568] [UniProtKB: P16406] There should be some charts here, you may need to enable JavaScript!
Aminopeptidase N in Pig [ChEMBL: CHEMBL2590] [UniProtKB: P15145] There should be some charts here, you may need to enable JavaScript!
Angiotensin-converting enzyme in Rat [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] There should be some charts here, you may need to enable JavaScript!
Neprilysin in Rabbit [ChEMBL: CHEMBL3768] [UniProtKB: P08049] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Glutamyl aminopeptidase/Aminopeptidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3439] [GtoPdb: 1568] [UniProtKB: Q07075]
ChEMBL	Binding affinity against recombinant Aminopeptidase A	B	9.06	pKi	0.87	nM	Ki	J Med Chem (1999) 42: 5197-5211 [PMID:10602705]
Glutamyl aminopeptidase in Mouse [GtoPdb: 1568] [UniProtKB: P16406]
GtoPdb	-	-	9.06	pKi	0.87	nM	Ki	J Med Chem (1999) 42: 5197-211 [PMID:10602705]
Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145]
ChEMBL	Binding affinity against aminopeptidase N from pig kidney	B	4.79	pKi	16400	nM	Ki	J Med Chem (1999) 42: 5197-5211 [PMID:10602705]
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820]
ChEMBL	Binding affinity against Angiotensin I converting enzyme from rat testis	B	6.59	pKi	259	nM	Ki	J Med Chem (1999) 42: 5197-5211 [PMID:10602705]
Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049]
ChEMBL	Binding affinity against NEP from rabbit kidney(neutral endopeptidase)	B	6.66	pKi	219	nM	Ki	J Med Chem (1999) 42: 5197-5211 [PMID:10602705]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]