compound 1b [PMID: 18078750] [Ligand Id: 8627] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL163454 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibition of human recombinant ACE by fluorescence assay | B | 6.28 | pKi | 520 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1] | ||||||||
| ChEMBL | Inhibition of human recombinant ACE2 by fluorescence assay | B | 5.85 | pKi | 1400 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| Carboxypeptidase A1 (pancreatic)/Carboxypeptidase A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2088] [GtoPdb: 1587] [UniProtKB: P15085] | ||||||||
| ChEMBL | Inhibition of human recombinant carboxy peptidase A1 by fluorescence assay | B | 6.51 | pKi | 310 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| GtoPdb | - | - | 6.51 | pKi | 310 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750] |
| Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
| ChEMBL | Inhibition of human recombinant NEP by fluorescence assay | B | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-737 [PMID:18078750] |
| GtoPdb | - | - | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750] |
| Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861] | ||||||||
| ChEMBL | Inhibition of neutral endopeptidase (NEP) 24.11 | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 735-738 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
