3S,4R-293B [Ligand Id: 8610] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL44297 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv7.1/Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221347] [GtoPdb: 560] [UniProtKB: P15382, P51787] | ||||||||
| ChEMBL | Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1) | B | 4.35 | pIC50 | 44500 | nM | IC50 | J Med Chem (2001) 44: 3831-3837 [PMID:11689069] |
| GtoPdb | - | - | 4.52 | pIC50 | 30100 | nM | IC50 | Br J Pharmacol (2001) 134: 1647-54 [PMID:11739240] |
| ChEMBL | Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 2) | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2001) 44: 3831-3837 [PMID:11689069] |
| Kv4.3/Voltage-gated potassium channel subunit Kv4.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1964] [GtoPdb: 554] [UniProtKB: Q9UK17] | ||||||||
| ChEMBL | The inhibitory concentration for 50% was measured on potassium channel complex | F | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2001) 44: 1627-1653 [PMID:11356099] |
| Voltage-gated potassium channel subunit Kv7.1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5135] [UniProtKB: O70344] | ||||||||
| ChEMBL | Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes | B | 4.41 | pIC50 | 39000 | nM | IC50 | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| ChEMBL | Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes | F | 5.21 | pIC50 | 6200 | nM | IC50 | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
