ChEMBL ligand: CHEMBL606201
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] Fatty acid amide hydrolase/Anandamide amidohydrolase in Mouse [ChEMBL: CHEMBL3455] [GtoPdb: 1400] [UniProtKB: O08914] There should be some charts here, you may need to enable JavaScript!
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0] There should be some charts here, you may need to enable JavaScript!
monoacylglycerol lipase/Monoglyceride lipase in Human [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685] monoacylglycerol lipase/Monoglyceride lipase in Mouse [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678] There should be some charts here, you may need to enable JavaScript!
Neuropathy target esterase in Mouse [ChEMBL: CHEMBL3259506] [UniProtKB: Q3TRM4] There should be some charts here, you may need to enable JavaScript!
acyloxyacyl hydrolase in Human [GtoPdb: 2873] [UniProtKB: P28039] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL	Inhibition of human recombinant FAAH using AMC-AA as substrate preincubated with enzyme for 10 mins followed by substrate addition for 2 hrs by fluorometric analysis	B	7.72	pIC50	19	nM	IC50	Eur J Med Chem (2022) 237: 114358-114358 [PMID:35462163]
ChEMBL	Inhibition of recombinant human FAAH using AMC-AA as substrate preincubated for 10 mins followed by substrate addition measured after 2 hrs by fluorometric assay	B	7.72	pIC50	19	nM	IC50	J Med Chem (2023) 66: 235-250 [PMID:36542836]
ChEMBL	Inhibition of recombinant human FAAH incubated for 5 mins followed by substrate addition by cayman fluorescence based multimode microplate reader assay	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem (2022) 60: 116698-116698 [PMID:35296453]
ChEMBL	Inhibition of recombinant FAAH (unknown origin) expressed in COS7 cells assessed as blockade of substrate hydrolysis using 2-AG as substrate preincubated with compound for 30 mins followed by substrate addition	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2022) 68: 128763-128763 [PMID:35500728]
GtoPdb	in vitro assay	-	8.7	pIC50	2	nM	IC50	Proc Natl Acad Sci USA (2009) 106: 20270-5 [PMID:19918051]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3455] [GtoPdb: 1400] [UniProtKB: O08914]
ChEMBL	Inhibition of FAAH in mouse brain membrane	B	7.89	pIC50	13	nM	IC50	J Med Chem (2010) 53: 1830-1842 [PMID:20099888]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
ChEMBL	Inhibition of ABHD6 in mouse brain membrane	B	7.3	pIC50	50	nM	IC50	J Med Chem (2010) 53: 1830-1842 [PMID:20099888]
monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685]
ChEMBL	Inhibition of human recombinant MAGL pre-incubated for 5 mins before MAGL substrate addition and further incubated for 10 mins	B	6.69	pIC50	204.5	nM	IC50	J Med Chem (2020) 63: 5783-5796 [PMID:32429662]
ChEMBL	Inhibition of human recombinant MAGL incubated for 5 mins followed by substrate addition by cayman fluorescence based multimode microplate reader assay	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2022) 60: 116698-116698 [PMID:35296453]
ChEMBL	Inhibition of recombinant MAGL (unknown origin) expressed in COS7 cells assessed as blockade of substrate hydrolysis using AEA as substrate preincubated with compound for 30 mins followed by susbstrate addition	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2022) 68: 128763-128763 [PMID:35500728]
GtoPdb	in vitro assay	-	8.4	pIC50	4	nM	IC50	Proc Natl Acad Sci USA (2009) 106: 20270-5 [PMID:19918051]
monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
ChEMBL	Inhibition of MAGL in mouse brain membrane	B	7.72	pIC50	19	nM	IC50	J Med Chem (2010) 53: 1830-1842 [PMID:20099888]
Neuropathy target esterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259506] [UniProtKB: Q3TRM4]
ChEMBL	Inhibition of NTE in mouse brain membrane	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2010) 53: 1830-1842 [PMID:20099888]
acyloxyacyl hydrolase in Human [GtoPdb: 2873] [UniProtKB: P28039]
GtoPdb	-	-	7.36	pIC50	44	nM	IC50	Nat Chem Biol (2014) 10: 656-63 [PMID:24997602]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]