ChEMBL ligand: CHEMBL1979298
Botulinum neurotoxin type F in Clostridium botulinum [ChEMBL: CHEMBL2007627] [UniProtKB: P30996] There should be some charts here, you may need to enable JavaScript!
Ras converting CAAX endopeptidase 1/Prenyl protein specific protease in Human [ChEMBL: CHEMBL3411] [GtoPdb: 2412] [UniProtKB: Q9Y256] There should be some charts here, you may need to enable JavaScript!
Protein disulfide-isomerase in Human [ChEMBL: CHEMBL5422] [UniProtKB: P07237] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Botulinum neurotoxin type F in Clostridium botulinum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007627] [UniProtKB: P30996]
ChEMBL	Inhibition of Botulinum neurotoxins/F	B	4.52	pIC50	30470	nM	IC50	J Med Chem (2021) 64: 16349-16379 [PMID:34779640]
Ras converting CAAX endopeptidase 1/Prenyl protein specific protease in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3411] [GtoPdb: 2412] [UniProtKB: Q9Y256]
GtoPdb	-	-	5.05	pIC50	9000	nM	IC50	J Biomol Screen (2007) 12: 983-93 [PMID:17942791]
ChEMBL	Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residual activity measured every 30 to 60 seconds for 60 mins	B	5.16	pIC50	6900	nM	IC50	Bioorg Med Chem (2016) 24: 160-178 [PMID:26706114]
Protein disulfide-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5422] [UniProtKB: P07237]
ChEMBL	Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrate preincubated for 1 hr followed by substrate addition	B	6.52	pIC50	300	nM	IC50	J Med Chem (2020) 63: 10263-10286 [PMID:32830969]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]