compound 9g [PMID: 24412111] [Ligand Id: 8509] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3115390 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247] | ||||||||
| ChEMBL | Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | B | 8.77 | pEC50 | 1.7 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 750-755 [PMID:24412111] |
| ChEMBL | Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay | B | 8.77 | pEC50 | 1.7 | nM | EC50 | Bioorg Med Chem (2015) 23: 89-104 [PMID:25497965] |
| GtoPdb | - | - | 8.77 | pEC50 | 1.7 | nM | EC50 |
Bioorg Med Chem Lett (2014) 24: 750-5 [PMID:24412111]; Peptides (2016) 75: 8-17 [PMID:26524625]; J Pharmacol Exp Ther (2022) 382: 66-78 [PMID:35644465] |
| BB3 receptor/Bombesin receptor subtype-3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075140] [GtoPdb: 40] [UniProtKB: O54798] | ||||||||
| ChEMBL | Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | B | 8.46 | pEC50 | 3.5 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 750-755 [PMID:24412111] |
| ChEMBL | Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay | B | 8.46 | pEC50 | 3.5 | nM | EC50 | Bioorg Med Chem (2015) 23: 89-104 [PMID:25497965] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
