ChEMBL ligand: CHEMBL502124
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2/cyclin A	B	4.8	pIC50	>16000	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of Aurora A in human HCT116 cells assessed as complete loss of phospho-Aurora A staining in centrosomes by immunofluorescence assay	B	5.6	pIC50	2500	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of N-terminal flag-tagged Aurora A T217E mutant expressed in Escherichia coli BL21-DE3	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of Aurora A in human HCT116 cells assessed as complete failure of centrosome seperation by immunofluorescence assay	B	6.41	pIC50	390	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of N-terminal flag-tagged Aurora A expressed in Escherichia coli BL21-DE3 by ELISA	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of Aurora A kinase (unknown origin)	B	8.47	pIC50	3.4	nM	IC50	Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
ChEMBL	Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG peptide as substrate incubated for 20 mins by Kinase-Glo plus luminescent kinase assay	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (2021) 64: 7312-7330 [PMID:34009981]
GtoPdb	-	-	8.47	pIC50	3.4	nM	IC50	J Med Chem (2009) 52: 3300-7 [PMID:19402633]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora B in human HCT116 cells assessed as complete loss of phospho-histamine H3 staining by immunofluorescence assay	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of Aurora B in human HT29 cells assessed as complete loss of phospho-histamine H3 staining by immunofluorescence assay	B	4.57	pIC50	>27000	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
ChEMBL	Inhibition of N-terminal flag-tagged Aurora B expressed in Escherichia coli BL21-DE3 by ELISA	B	5.47	pIC50	3400	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]
GtoPdb	-	-	5.47	pIC50	3400	nM	IC50	J Med Chem (2009) 52: 3300-7 [PMID:19402633]
ChEMBL	Inhibition of N-terminal flag-tagged Aurora B E161T mutant expressed in Escherichia coli BL21-DE3	B	7.26	pIC50	55	nM	IC50	J Med Chem (2009) 52: 3300-3307 [PMID:19402633]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]