droxinostat [Ligand Id: 8464] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1526649
  • histone deacetylase 3 in Human [GtoPdb: 2617] [UniProtKB: O15379]
Created with Highcharts 10.3.3ValuesChart context menuhistone deacetylase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • histone deacetylase 6 in Human [GtoPdb: 2618] [UniProtKB: Q9UBN7]
Created with Highcharts 10.3.3ValuesChart context menuhistone deacetylase 6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • histone deacetylase 8 in Human [GtoPdb: 2619] [UniProtKB: Q9BY41]
Created with Highcharts 10.3.3ValuesChart context menuhistone deacetylase 8pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
histone deacetylase 3 in Human [GtoPdb: 2617] [UniProtKB: O15379]
GtoPdb - - 4.77 pIC50 16900 nM IC50 Mol Cancer Ther (2010) 9: 246-56 [PMID:20053768]
histone deacetylase 6 in Human [GtoPdb: 2618] [UniProtKB: Q9UBN7]
GtoPdb - - 5.61 pIC50 2470 nM IC50 Mol Cancer Ther (2010) 9: 246-56 [PMID:20053768]
histone deacetylase 8 in Human [GtoPdb: 2619] [UniProtKB: Q9BY41]
GtoPdb - - 5.84 pIC50 1460 nM IC50 Mol Cancer Ther (2010) 9: 246-56 [PMID:20053768]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]