AS-19 [Ligand Id: 8433] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2164327 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Displacement of [3H]-5-carboxamidotryptamine from human 5-HT1A receptor expressed in HEK293T cell membranes incubated for 90 mins by scintillation counting method | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem (2020) 28: 115262-115262 [PMID:31882369] |
| ChEMBL | Antagonist activity at 5-HT1A receptor (unknown origin) | B | 7.05 | pKi | 89.7 | nM | Ki | Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003] |
| ChEMBL | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor after 60 mins by scintillation counting analysis | B | 7.05 | pKi | 89.7 | nM | Ki | Medchemcomm (2018) 9: 1882-1890 [PMID:30568756] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Displacement of [3H]LSD from recombinant human 5-HT5a receptor after 120 mins by scintillation counting analysis | B | 7.01 | pKi | 98.5 | nM | Ki | Medchemcomm (2018) 9: 1882-1890 [PMID:30568756] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem (2020) 28: 115262-115262 [PMID:31882369] |
| GtoPdb | - | - | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem (2013) 21: 2568-76 [PMID:23541835] |
| ChEMBL | Binding affinity to human 5HT7 receptor expressed in HEK-293F cells | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem (2013) 21: 2568-2576 [PMID:23541835] |
| ChEMBL | Binding affinity to 5-HT7 receptor (unknown origin) | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2018) 61: 8475-8503 [PMID:29767995] |
| ChEMBL | Antagonist activity at 5-HT7 receptor (unknown origin) | B | 9.22 | pKi | 0.6 | nM | Ki | Eur J Med Chem (2019) 183: 111705-111705 [PMID:31581003] |
| ChEMBL | Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis | B | 9.22 | pKi | 0.6 | nM | Ki | Medchemcomm (2018) 9: 1882-1890 [PMID:30568756] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
