EMD-386088 [Ligand Id: 8428] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL364005 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat | B | 6.18 | pIC50 | 660 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1B receptor in calf | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT1B receptor/5-hydroxytryptamine receptor 1B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat | B | 6.74 | pIC50 | 180 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 2A receptor in human | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 2C receptor in human | B | 6.35 | pIC50 | 450 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT3A/5-hydroxytryptamine receptor 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-hydroxytryptamine receptor 4 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig | B | 6.21 | pIC50 | 620 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| 5-HT6 receptor/5-hydroxytryptamine receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| GtoPdb | - | - | 8.13 | pIC50 | 7.4 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4230-4 [PMID:16055331] |
| ChEMBL | Displacement of [3H]LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells | B | 8.13 | pIC50 | 7.4 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 6 receptor in human | B | 8.13 | pIC50 | 7.4 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
| ChEMBL | Partial agonist activity at 5-HT6 receptor (unknown origin) | F | 9 | pEC50 | 1 | nM | EC50 | J Med Chem (2024) 67: 1580-1610 [PMID:38190615] |
| 5-HT7 receptor/5-hydroxytryptamine receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 7 receptor in human | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
