UK-432,097 [Ligand Id: 8420] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1096896 (Uk432097)
  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 8.3 pKi - - - Science (2011) 332: 322-7 [PMID:21393508];
Br J Pharmacol (2012) 166: 1846-59 [PMID:22324512]
ChEMBL Binding affinity to A2A adenosine receptor B 8.4 pKi 4 nM Ki J Med Chem (2012) 55: 538-552 [PMID:22104008]
ChEMBL Binding affinity to human adenosine A2A receptor B 8.4 pKi 4 nM Ki J Med Chem (2015) 58: 3253-3267 [PMID:25780876]
ChEMBL Agonist activity at adenosine A2A receptor in fMLP-stimulated human neutrophils assessed as inhibition of superoxide production by colorimetric analysis F 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2009) 19: 4471-4475 [PMID:19501510]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]