ChEMBL ligand: CHEMBL1800807 (Anacetrapib, MK-0859, MK0859)
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597]
ChEMBL	Inhibition of full-length human recombinant CETP expressed in CHO cells by BODIPY-CE dye based fluorescence assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2016) 24: 1811-1818 [PMID:26993745]
ChEMBL	Inhibition of CETP in 95% human serum assessed as inhibition of transfer of [3H] cholesteryl oleate or [3H] triolein between LDL and HDL	B	7.28	pIC50	53	nM	IC50	Bioorg Med Chem Lett (2021) 32: 127668-127668 [PMID:33161125]
ChEMBL	Inhibition of CETP in human plasma assessed as reduction in fluorescent intensity by fluorescence analysis	B	7.34	pIC50	46	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3056-3062 [PMID:22497761]
ChEMBL	Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein between exogenous [3H]LDL in 95% human serum by liquid scintillation analysis	B	7.35	pIC50	45	nM	IC50	J Med Chem (2021) 64: 13215-13258 [PMID:34375108]
ChEMBL	Inhibition of recombinant CETP (unknown origin) assessed as inhibition of BODIPY-labeled cholesteryl transfer to fluorescent substrate by fluorimetric assay	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2016) 123: 419-430 [PMID:27490022]
ChEMBL	Inhibition of recombinant full length human CETP expressed in CHO cells assessed as reduction in BODIPY-CE transfer measured after 1 to 3 hrs by fluorescence assay	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 126: 143-153 [PMID:27750148]
ChEMBL	Inhibition of human CETP	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126824-126824 [PMID:31780304]
ChEMBL	Inhibition of recombinant human CETP after 3 hrs using fluorescent cholesteryl containing HDL after 3 hrs by fluorescence assay	B	7.47	pIC50	33.8	nM	IC50	Eur J Med Chem (2017) 139: 201-213 [PMID:28802120]
ChEMBL	Inhibition of CETP in human plasma measured every 30 mins for 120 mins by fluorescence method	B	7.74	pIC50	18	nM	IC50	J Med Chem (2017) 60: 8466-8481 [PMID:29035537]
GtoPdb	-	-	7.76	pIC50	17.2	nM	IC50	J Med Chem (2011) 54: 4880-95 [PMID:21682257]
ChEMBL	Inhibition of human recombinant CETP-mediated cholesteryl ester transfer activity after 1 hr by fluorescent cholesteryl esters transfer assay	B	7.76	pIC50	17.2	nM	IC50	J Med Chem (2011) 54: 4880-4895 [PMID:21682257]
ChEMBL	Inhibition of CETP-mediated neutral lipid transfer by fluorometric analysis	B	7.76	pIC50	17.2	nM	IC50	Bioorg Med Chem Lett (2012) 22: 199-203 [PMID:22142541]
ChEMBL	Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein using exogenous LDL and HDL in 2% human serum by liquid scintillation analysis	B	7.77	pIC50	17	nM	IC50	J Med Chem (2021) 64: 13215-13258 [PMID:34375108]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of [S35]-MK-0499 binding to human ERG expressed in HEK293 cells	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2021) 64: 13215-13258 [PMID:34375108]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]