CHR-3996 [Ligand Id: 8391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1801250 (Hdac inhibitor chr-3996, CHR-3996, Chr 3996, VRX-3996, Nanatinostat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| ChEMBL | Inhibition of human recombinant HDAC1 using fluor de Lys as substrate by fluorometric analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| ChEMBL | Inhibition of human recombinant HDAC3 using fluor de Lys as substrate by fluorometric analysis | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC5 using fluor de Lys as substrate by fluorometric analysis | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
| histone deacetylase 6/Protein deacetylase HDAC6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC6 using fluor de Lys as substrate by fluorometric analysis | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 8663-8678 [PMID:21080647] |
| GtoPdb | - | - | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 8663-78 [PMID:21080647] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
