SD-208 [Ligand Id: 8246] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL238125 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Inhibition of PKD1 autophosphorylation at S916 residue in human LNCaP cells | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Med Chem (2023) 66: 122-139 [PMID:36538005] |
| ChEMBL | Inhibition of PKD1 (unknown origin) | B | 6.97 | pIC50 | 106 | nM | IC50 | J Med Chem (2023) 66: 122-139 [PMID:36538005] |
| protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| ChEMBL | Inhibition of PKD3 (unknown origin) | B | 6.98 | pIC50 | 105 | nM | IC50 | J Med Chem (2023) 66: 122-139 [PMID:36538005] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Inhibition of PKD2 (unknown origin) | B | 7.03 | pIC50 | 94 | nM | IC50 | J Med Chem (2023) 66: 122-139 [PMID:36538005] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of TGFBR1 | B | 7.28 | pIC50 | 53 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 1843-1849 [PMID:17289388] |
| GtoPdb | - | - | 7.28 | pIC50 | 53 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 1843-9 [PMID:17289388] |
| ChEMBL | Inhibition of TbetaR-1 (unknown origin) | B | 7.32 | pIC50 | 48 | nM | IC50 | Eur J Med Chem (2020) 191: 112154-112154 [PMID:32092587] |
| ChEMBL | Inhibition of TGFBR1 (unknown origin) | B | 7.46 | pIC50 | 35 | nM | IC50 | Eur J Med Chem (2019) 163: 413-427 [PMID:30530193] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
