ChEMBL ligand: CHEMBL3261514
casein kinase 1 alpha 1/Casein kinase I alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] There should be some charts here, you may need to enable JavaScript!
casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 9/CDK9/cyclin T1 in Human [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL	Inhibition of CK1alpha (unknown origin) by TR-FRET assay	B	6.16	pIC50	694	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL	Inhibition of CK1delta (unknown origin) by TR-FRET assay	B	7.08	pIC50	84	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibition of CK2 (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.54	pIC50	29100	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cell division cycle 7/CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111377] [GtoPdb: 1960] [UniProtKB: O00311, Q9UBU7]
ChEMBL	Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs	B	6.3	pIC50	501	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 54 uM of ATP as substrate by AlphaScreen assay	B	7.07	pIC50	86	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.074 uM of ATP as substrate by AlphaScreen assay	B	7.19	pIC50	64	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.037 uM of ATP as substrate by AlphaScreen assay	B	7.2	pIC50	63	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 27 uM of ATP as substrate by AlphaScreen assay	B	7.36	pIC50	44	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.025 uM of ATP as substrate by AlphaScreen assay	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.222 uM of ATP as substrate by AlphaScreen assay	B	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.111 uM of ATP as substrate by AlphaScreen assay	B	7.54	pIC50	29	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 18 uM of ATP as substrate by AlphaScreen assay	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.333 uM of ATP as substrate by AlphaScreen assay	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 9 uM of ATP as substrate by AlphaScreen assay	B	7.74	pIC50	18	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.012 uM of ATP as substrate by AlphaScreen assay	B	7.77	pIC50	17	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 0.667 uM of ATP as substrate by AlphaScreen assay	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 6 uM of ATP as substrate by AlphaScreen assay	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 1 uM of ATP as substrate by AlphaScreen assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin) using 2 uM of ATP as substrate by AlphaScreen assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
GtoPdb	-	-	8.42	pIC50	3.77	nM	IC50	Eur J Med Chem (2014) 80: 364-82 [PMID:24793884]
ChEMBL	Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay	B	8.42	pIC50	3.77	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750]
ChEMBL	Inhibition of CDK9/Cyclin-T1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	6.13	pIC50	749	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635]
ChEMBL	Inhibition of CDK1/Cyclin-B (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941]
ChEMBL	Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay	B	5.74	pIC50	1820	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385]
ChEMBL	Inhibition of CDK4/Cyclin-D1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of Pim1 (unknown origin) by homogeneous time-resolved fluorescence assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2014) 80: 364-382 [PMID:24793884]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]