compound R-16 [PMID: 21967808] [Ligand Id: 8213] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1939491
  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay B 7.59 pIC50 26 nM IC50 Bioorg Med Chem (2011) 19: 6274-6284 [PMID:21967808]
ChEMBL Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence assay B 7.62 pIC50 24 nM IC50 Bioorg Med Chem (2011) 19: 6274-6284 [PMID:21967808]
GtoPdb - - 7.62 pIC50 24 nM IC50 Bioorg Med Chem (2011) 19: 6274-84 [PMID:21967808]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay B 5.85 pIC50 1418 nM IC50 Bioorg Med Chem (2011) 19: 6274-6284 [PMID:21967808]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]