compound 1 [PMID: 21742770] [Ligand Id: 8190] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2203524
  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • protein kinase A in Human [GtoPdb: 1694]
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  • aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
GtoPdb - - 8.15 pIC50 7 nM IC50 Cancer Res (2011) 71: 5818-26 [PMID:21742770]
ChEMBL Inhibition of N-terminal 6His-tagged full length human recombinant STK33 using myelin basic protein as substrate incubated for 15 mins before initiation of kinase reaction measured after 1 hr by ADP-glo assay B 8.15 pIC50 7 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb - - 6.71 pIC50 196 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]
aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb - - 8.55 pIC50 2.8 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]