Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL226403 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
GtoPdb | - | - | 8.07 | pIC50 | 8.5 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
ChEMBL | Inhibition of MK2 | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL | Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J Med Chem (2008) 51: 6225-6229 [PMID:18771253] |
ChEMBL | Inhibition of MK2 pretreated for 30 mins before substrate addition measured after 2 hrs by IMAP assay | B | 7.31 | pEC50 | 49 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 3818-3822 [PMID:21565500] |
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
ChEMBL | Inhibition of MK3 | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
GtoPdb | - | - | 6.09 | pIC50 | 810 | nM | IC50 | J Med Chem (2007) 50: 2647-54 [PMID:17480064] |
ChEMBL | Inhibition of MAPKAPK5 (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2013) 56: 6991-7002 [PMID:23937569] |
ChEMBL | Inhibition of MK5 | B | 7.09 | pIC50 | 81 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 5.46 | pIC50 | 3440 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.24 | pIC50 | 5700 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of p38alpha | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2007) 50: 2647-2654 [PMID:17480064] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]