compound 33 [PMID: 19364658] | Ligand Activity Charts

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compound 33 [PMID: 19364658]
Ligand Activity Charts

compound 33 [PMID: 19364658] [Ligand Id: 8163] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL511410
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] There should be some charts here, you may need to enable JavaScript!
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] There should be some charts here, you may need to enable JavaScript!
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Human [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL	Inhibition of CK1-gamma1	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.8	pIC50	160	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL	Inhibition of IKKalpha	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL	Inhibition of human recombinant MK2	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of ERK2	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of p38alpha	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibition of PDGFRalpha	B	4.95	pIC50	11100	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL	Inhibition of PKCalpha	B	4.47	pIC50	33600	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
ChEMBL	Inhibition of ROCK1	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL	Inhibition of RSK1	B	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora B	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	Inhibition of FYN	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of SRC	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb	-	-	6.57	pIC50	270	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757]
GtoPdb	-	-	7.05	pIC50	90	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]