compound 9b [PMID: 18986805] [Ligand Id: 8160] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL455428
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb - - 9 pIC50 <1 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK2 B 9 pIC50 <1 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
GtoPdb - - 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK4 B 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK1 B 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of FGFR1 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by patch clamp assay B 4.8 pIC50 16000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of IGF1R B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Inhibition of Csk B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of Zap70 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]