compound 9b [PMID: 18986805] [Ligand Id: 8160] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL455428
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb - - 9 pIC50 <1 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK2 B 9 pIC50 <1 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
GtoPdb - - 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK4 B 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]
ChEMBL Inhibition of CDK1 B 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of FGFR1 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by patch clamp assay B 4.8 pIC50 16000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of IGF1R B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Inhibition of Csk B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of Zap70 B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 6486-9 [PMID:18986805]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]