Il-94 [Ligand Id: 8132] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2386715
  • p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
There should be some charts here, you may need to enable JavaScript!
  • p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
There should be some charts here, you may need to enable JavaScript!
  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
GtoPdb - - 7.43 pKi 36.8 nM Ki ACS Med Chem Lett (2013) 4: 431-2 [PMID:24900689]
ChEMBL Inhibition of human recombinant GST-tagged PAK1 kinase domain-mediated 5FAM-RRRLSFAEPG phosphorylation expressed in Sf9 cells preincubated for 10 mins prior to substrate addition measured after 30 mins by microfluidic mobility shift assay B 7.43 pKi 36.8 nM Ki ACS Med. Chem. Lett. (2013) 4: 431-432 [PMID:24900689]
ChEMBL Inhibition of PAK1-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assay B 7.19 pIC50 64.1 nM IC50 ACS Med. Chem. Lett. (2013) 4: 431-432 [PMID:24900689]
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
GtoPdb - - 7.19 pIC50 64.1 nM IC50 ACS Med Chem Lett (2013) 4: 431-2 [PMID:24900689]
ChEMBL Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assay B 7.19 pIC50 64.1 nM IC50 ACS Med. Chem. Lett. (2013) 4: 431-432 [PMID:24900689]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Inhibition of PAK3-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assay B 7.19 pIC50 64.1 nM IC50 ACS Med. Chem. Lett. (2013) 4: 431-432 [PMID:24900689]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]