ChEMBL ligand: CHEMBL501724
casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400] There should be some charts here, you may need to enable JavaScript!
cell division cycle 7/Cell division cycle 7-related protein kinase in Human [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 1/Dual specificity protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!
Casein kinase 2 in Human [GtoPdb: 1548] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400]
ChEMBL	Inhibition of human tertrameric CK2alphabeta holoenzyme using casein as substrate after 1 to 2 hrs by chemiluminescence assay in presence of 2 uM ATP	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567]
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
ChEMBL	Inhibition of CDC7-DBF4	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4482-4485 [PMID:18672368]
GtoPdb	-	-	8.85	pIC50	1.4	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567]
ChEMBL	Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP	B	8.85	pIC50	1.4	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL	Inhibition of CLK1	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469]
GtoPdb	-	-	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of human GSK3-beta expressed in CHO AA8 cells co-expressing human tau protein after 2 hrs	B	5.28	pIC50	>5280	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469]
GtoPdb	-	-	7.76	pIC50	17.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469]
ChEMBL	Inhibition of human recombinant GSK3-beta expressed in baculovirus infected SF9 cells after 60 mins	B	7.76	pIC50	17.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assay	B	6.48	pIC50	332	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567]
GtoPdb	-	-	6.48	pIC50	332	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567]
Casein kinase 2 in Human [GtoPdb: 1548]
GtoPdb	-	-	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567]; Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]