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ChEMBL ligand: CHEMBL524266 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of ALK | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
ChEMBL | Inhibition of PKAalpha | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
GtoPdb | CDK2/cyclin A complex | - | 6.86 | pIC50 | 138 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of Cdk2A | B | 6.86 | pIC50 | 138 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Inhibition of CDK4 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of CDK5/p25 | B | 5.79 | pIC50 | 1620 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
GtoPdb | CDK9/cyclin T complex | - | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of CDK9 | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
ChEMBL | Inhibition of FGFR1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 6.84 | pIC50 | 146 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
GtoPdb | - | - | 6.84 | pIC50 | 146 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of MET | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
High affinity immunoglobulin gamma Fc receptor I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5349] [UniProtKB: P12314] | ||||||||
ChEMBL | Inhibition of IGFR1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of IKKi | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of IR | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
ChEMBL | Inhibition of MK2 | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of ERK2 | B | 6.07 | pIC50 | 846 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Inhibition of P38beta | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
ChEMBL | Inhibition of TRKA | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of PKCbeta | B | 5.94 | pIC50 | 1149 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of PDK1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
ChEMBL | Inhibition of STLK2 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of AKT1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Inhibition of AUR2 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL | Inhibition of AUR1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
ChEMBL | Inhibition of MST4 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
ChEMBL | Inhibition of NEK6 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
ChEMBL | Inhibition of NIM1 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
GtoPdb | - | - | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
ChEMBL | Inhibition of PAK4 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
ChEMBL | Inhibition of PLK1 | B | 6.24 | pIC50 | 574 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
ChEMBL | Inhibition of TAO3 | B | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
GtoPdb | - | - | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of KIT | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of ABL | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Inhibition of RET | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
ChEMBL | Inhibition of VEGFR3 | B | 5.4 | pIC50 | >4000 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
GtoPdb | CDK1/cyclin B complex | - | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2009) 52: 293-307 [PMID:19115845] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]