tasquinimod [Ligand Id: 8098] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2107784 (Tasquinimod) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| GtoPdb | - | - | 8 | pKd | 10 | nM | Kd | Cancer Res (2013) 73: 1386-99 [PMID:23149916] |
| ChEMBL | Binding affinity to human full length N-terminal GST-tagged HDAC4 by surface plasmon resonance analysis | B | 8 | pKd | 10 | nM | Kd | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of human N-terminal flag-tag full-length wild-type HDAC4 by surface plasmon resonance assay | B | 8 | pKd | 10 | nM | Kd | Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
