ChEMBL ligand: CHEMBL2216824
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL	Inhibition of Nano-Luc fused JNK1 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after 1 hr by NanoBRET assay	B	7.59	pIC50	26	nM	IC50	J Med Chem (2023) 66: 3356-3371 [PMID:36826833]
ChEMBL	Inhibition of JNK1 (unknown origin) after 1 hr incubation	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK1 (unknown origin) incubated for 1 hrs	B	8.33	pIC50	4.7	nM	IC50	Eur J Med Chem (2023) 256: 115442-115442 [PMID:37156184]
ChEMBL	Inhibition of JNK1	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
ChEMBL	Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assay	B	8.33	pIC50	4.7	nM	IC50	J Med Chem (2023) 66: 3356-3371 [PMID:36826833]
GtoPdb	-	-	8.33	pIC50	4.7	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK1 (unknown origin)	B	8.33	pIC50	4.67	nM	IC50	J Med Chem (2022) 65: 3758-3775 [PMID:35200035]
ChEMBL	Inhibition of JNK1 (unknown origin) after 1 hr	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL	Inhibition of Nano-Luc fused JNK2 (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K5-tarcer addition and measured after 1 hr by NanoBRET assay	B	7.34	pIC50	46	nM	IC50	J Med Chem (2023) 66: 3356-3371 [PMID:36826833]
ChEMBL	Inhibition of JNK2 (unknown origin)	B	7.73	pIC50	18.7	nM	IC50	J Med Chem (2022) 65: 3758-3775 [PMID:35200035]
ChEMBL	Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assay	B	7.73	pIC50	18.7	nM	IC50	J Med Chem (2023) 66: 3356-3371 [PMID:36826833]
ChEMBL	Inhibition of JNK2 (unknown origin) incubated for 1 hrs	B	7.73	pIC50	18.7	nM	IC50	Eur J Med Chem (2023) 256: 115442-115442 [PMID:37156184]
ChEMBL	Inhibition of JNK2	B	7.73	pIC50	18.7	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
GtoPdb	-	-	7.73	pIC50	18.7	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK2 (unknown origin) after 1 hr	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
ChEMBL	Inhibition of JNK2 (unknown origin) after 1 hr incubation	B	9	pIC50	1	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL	Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation	B	6.31	pIC50	486	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation	B	6.47	pIC50	338	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Chem Biol (2012) 19: 140-54 [PMID:22284361]
ChEMBL	Inhibition of JNK3 (unknown origin) after 1 hr incubation	B	9	pIC50	1	nM	IC50	J Med Chem (2015) 58: 72-95 [PMID:25415535]
ChEMBL	Inhibition of JNK3 (unknown origin) after 1 hr by FRET-based assay	B	9	pIC50	1	nM	IC50	J Med Chem (2017) 60: 839-885 [PMID:27996267]
ChEMBL	Inhibition of JNK3 (unknown origin) incubated for 1 hrs	B	9	pIC50	1	nM	IC50	Eur J Med Chem (2023) 256: 115442-115442 [PMID:37156184]
ChEMBL	Inhibition of JNK3	B	9.01	pIC50	0.98	nM	IC50	J Med Chem (2012) 55: 6243-6262 [PMID:22621397]
ChEMBL	Inhibition of JNK3 (unknown origin)	B	9.01	pIC50	0.98	nM	IC50	J Med Chem (2022) 65: 3758-3775 [PMID:35200035]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]