ChEMBL ligand: CHEMBL1081312
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha in Human [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
HCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2032] [UniProtKB: P08631] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
protein kinase, DNA-activated, catalytic subunit in Human [GtoPdb: 2800] [UniProtKB: P78527] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb	-	-	6.59	pIC50	260	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
platelet derived growth factor receptor alpha in Human [GtoPdb: 1803] [UniProtKB: P16234]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb	-	-	7.92	pIC50	12	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519]
GtoPdb	-	-	7.74	pIC50	18	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
HCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2032] [UniProtKB: P08631]
GtoPdb	-	-	8.1	pIC50	8	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb	-	-	8	pIC50	10	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb	-	-	7.28	pIC50	52	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb	-	-	5.85	pIC50	1400	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb	-	-	6.82	pIC50	150	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	-	-	5.96	pIC50	1100	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb	-	-	7.85	pIC50	14	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]
protein kinase, DNA-activated, catalytic subunit in Human [GtoPdb: 2800] [UniProtKB: P78527]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	Nat Chem Biol (2008) 4: 691-9 [PMID:18849971]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]