KU-0060648 [Ligand Id: 8011] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086377 (KU-0060648) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of DNA-dependent protein kinase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 3649-3653 [PMID:20472428] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 966-970 [PMID:21216595] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5352-5359 [PMID:22835870] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2012) 57: 85-101 [PMID:23059543] |
| ChEMBL | Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| ChEMBL | Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cells | B | 6.87 | pEC50 | 136 | nM | EC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG expressed in cisapride treated CHO cells by Ion Works assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Inhibition of PI-3K alpha (unknown origin) | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| GtoPdb | - | - | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of PI-3K beta (unknown origin) | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| GtoPdb | - | - | 10 | pIC50 | <0.1 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of PI-3K delta (unknown origin) | B | 10 | pIC50 | <0.1 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| ChEMBL | Inhibition of PI-3K gamma (unknown origin) | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| GtoPdb | - | - | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ATM serine/threonine kinase/Serine-protein kinase ATM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315] | ||||||||
| ChEMBL | Inhibition of ATM (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| ATR serine/threonine kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535] | ||||||||
| ChEMBL | Inhibition of ATR (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | Inhibition of mTOR (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
