KU-0060648 [Ligand Id: 8011] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086377 (KU-0060648) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of DNA-dependent protein kinase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 3649-3653 [PMID:20472428] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 966-970 [PMID:21216595] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5352-5359 [PMID:22835870] |
| ChEMBL | Inhibition of DNA-PK | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2012) 57: 85-101 [PMID:23059543] |
| ChEMBL | Inhibition of human DNA-PK using GST-tagged p53N66 as substrate after 1 hr by ELISA-based chemiluminiscence assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| ChEMBL | Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cells | B | 6.87 | pEC50 | 136 | nM | EC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG expressed in cisapride treated CHO cells by Ion Works assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Inhibition of PI-3K alpha (unknown origin) | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| GtoPdb | - | - | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of PI-3K beta (unknown origin) | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| GtoPdb | - | - | 10 | pIC50 | <0.1 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ChEMBL | Inhibition of PI-3K delta (unknown origin) | B | 10 | pIC50 | <0.1 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| ChEMBL | Inhibition of PI-3K gamma (unknown origin) | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| GtoPdb | - | - | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 6386-401 [PMID:23855836] |
| ATM serine/threonine kinase/Serine-protein kinase ATM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315] | ||||||||
| ChEMBL | Inhibition of ATM (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| ATR serine/threonine kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535] | ||||||||
| ChEMBL | Inhibition of ATR (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | Inhibition of mTOR (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2013) 56: 6386-6401 [PMID:23855836] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
