WP1066 [Ligand Id: 7972] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1923234 (Wp 1066, Wp1066, WP-1066) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
| ChEMBL | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter gene expression measured after 20 hrs by microplate reader | B | 5.6 | pIC50 | 2500 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| ChEMBL | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter gene expression by microplate reader | B | 5.75 | pIC50 | 1790 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| GtoPdb | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells, determined in a secreted embryonic alkaline phosphatase reporter gene assay | - | 5.75 | pIC50 | 1790 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| Kv1.3 in Human [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
| GtoPdb | - | - | 5.49 | pIC50 | 3200 | nM | IC50 | Br J Pharmacol (2021) 178: 2617-2631 [PMID:33689167] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
