WP1066 [Ligand Id: 7972] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1923234 (Wp 1066, Wp1066, WP-1066) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
| ChEMBL | Inhibition of STAT3 in human HEK293 cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation incubated for 24 hrs by dual-luciferase reporter assay | B | 5.19 | pIC50 | 6440 | nM | IC50 | J Med Chem (2023) 66: 3106-3133 [PMID:36786551] |
| ChEMBL | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter gene expression measured after 20 hrs by microplate reader | B | 5.6 | pIC50 | 2500 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| ChEMBL | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter gene expression by microplate reader | B | 5.75 | pIC50 | 1790 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| GtoPdb | Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells, determined in a secreted embryonic alkaline phosphatase reporter gene assay | - | 5.75 | pIC50 | 1790 | nM | IC50 | ACS Med Chem Lett (2021) 12: 696-703 [PMID:34055214] |
| Kv1.3 in Human [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
| GtoPdb | - | - | 5.49 | pIC50 | 3200 | nM | IC50 | Br J Pharmacol (2021) 178: 2617-2631 [PMID:33689167] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
