ChEMBL ligand: CHEMBL3086767
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of recombinant full length C-terminal FLAG-tagged/C-terminal His-tagged human HDAC1 using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of recombinant N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL	Inhibition of full length recombinant human HDAC11 expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL	Inhibition of recombinant full length C-terminal His-tagged human HDAC2 expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
ChEMBL	Inhibition of full length recombinant human HDAC2 expressed in baculovirus expression system using fluorogenic peptide RHKK(Ac) as substrate by fluorescence assay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
ChEMBL	Inhibition of full length recombinant human HDAC2 expressed in baculovirus expression system using fluorogenic peptide RHKK(Ac) as substrate by fluorescence assay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
GtoPdb	-	-	9.92	pIC50	0.12	nM	IC50	J Nat Prod (2013) 76: 2026-33 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	B	9.92	pIC50	0.12	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC2 after 30 mins by fluorescence assay	B	9.95	pIC50	0.11	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
ChEMBL	Inhibition of recombinant full length C-terminal His-tagged human HDAC3/GST-tagged human Ncor2 (395 to 489 residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL	Inhibition of recombinant C-terminal His-tagged/N-terminal GST-tagged human HDAC4 (627 to 1084 residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	J Nat Prod (2013) 76: 2026-33 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC4 after 30 mins by fluorescence assay	B	6	pIC50	>1000	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC4 after 30 mins by fluorescence assay	B	6	pIC50	>1000	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
ChEMBL	Inhibition of recombinant C-terminal His-tagged human HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
GtoPdb	-	-	6.36	pIC50	434	nM	IC50	J Nat Prod (2013) 76: 2026-33 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC6 after 30 mins by fluorescence assay	B	6.36	pIC50	433.5	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
ChEMBL	Inhibition of human recombinant HDAC6 after 30 mins by fluorescence assay	B	6.36	pIC50	433	nM	IC50	J Nat Prod (2013) 76: 2026-2033 [PMID:24164245]
histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
ChEMBL	Inhibition of recombinant N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL	Inhibition of recombinant full length C-terminal His-tagged human HDAC8 expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]
histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
ChEMBL	Inhibition of recombinant C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem (2016) 24: 5183-5196 [PMID:27614919]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]