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ChEMBL ligand: CHEMBL203665 (Relacatib, SB-462795) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
ChEMBL | Inhibition of human cathepsin B | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
ChEMBL | Inhibition of cathepsin B in human HepG2 cells | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
GtoPdb | - | - | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (2010) 53: 4332-53 [PMID:20218623] |
ChEMBL | Inhibition of human cathepsin K | B | 10.39 | pKi | 0.04 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
ChEMBL | Inhibition of cathepsin K | B | 10.39 | pKi | 0.04 | nM | Ki | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236] | ||||||||
ChEMBL | Inhibition of rabbit cathepsin K | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin K/Cathepsin K in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3034] [GtoPdb: 2350] [UniProtKB: O35186] | ||||||||
ChEMBL | Inhibition of rat cathepsin K | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
ChEMBL | Inhibition of human cathepsin L | B | 10.17 | pKi | 0.07 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
ChEMBL | Inhibition of cathepsin L in human HepG2 cells | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
ChEMBL | Inhibition of human cathepsin V | B | 10.2 | pKi | 0.06 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
ChEMBL | Inhibition of human cathepsin S | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2006) 49: 1597-1612 [PMID:16509577] |
ChEMBL | Inhibition of cathepsin S in human ramos cells | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]